CURRICULUM
VITAE
JOHN EMANUEL
POULOS, M.D.
FACILITY ASSOCIATIONS:
|
Cape
Fear Valley Medical Center P.O.
Box 2000 1638
Owen Drive Fayetteville,
N.C. 28302-2000 |
Highsmith-Rainey
Memorial Hospital 150
Robeson Street Fayetteville,
N.C. 28301 |
Fayetteville
Ambulatory Surgery Center 1781
Metromedical Drive Fayetteville,
N.C. 28304 |
EDUCATION AND TRAINING:
1981-1985 East Carolina University,
B.S. in Biology, Minor in Chemistry
1985-1987 East Carolina University,
M.S. in Biology
1987-1991 East Carolina University
School of Medicine, M.D.
1991-1992 Intern, Department of
Internal Medicine, University of South Florida
College of
Medicine
1992-1994 Resident, Department of
Internal Medicine, University of South Florida
College of
Medicine
1994-1995 Post-doctoral Research
Fellow, Division of Gastroenterology/Hepatology,
Saint Louis
University Health Sciences Center
1995-1998 Subspecialty Resident,
Division of Gastroenterology/Hepatology, Saint Louis University Health Sciences
Center
HONORS AND AWARDS:
1987 Fulbright Nominee,
East Carolina University
1988 James McDaniels
Outstanding Graduate Student Award, East Carolina
University,
Department of Biology
1988 Summer Research
Award, East Carolina University School of Medicine
1988 Outstanding
American College Student
1991 Resident of the
Month, James A. Haley Veteran's Hospital
1993 Outstanding Poster
Presentation, Florida Chapter of the American College of Physicians
1994 Who's Who in the
South and Southwest
1994 American College of
Physician Resident of the Year, Florida Chapter
1995 Winner, Clinical
Vignette Competition American College of Physicians
National
Meeting
1995,
1996 Poster Finalist,
American College of Physicians National Meeting
1997 American Liver
Foundation Postdoctoral Research Fellow Award
1997 American Liver
Foundation Fellow Research Prize
BOARD CERTIFICATION:
National
Board of Medical Examiners
Diplomate
American
Board of Internal Medicine
Diplomate
Subspecialty
Board in Gastroenterology
MEMBERSHIP IN PROFESSIONAL
SOCIETIES:
American College of Physicians, 1991
to present
American College of
Gastroenterology, 1995 to present
American Gastroenterological
Association, 1997
American Association for the Study
of Liver Disease, 1999
PUBLICATIONS:
1.
Caro,
J.F., J.E. Poulos, O. Ittoop, and W. Pories. Insulin-like growth factor 1 binding in hepatocytes from human
liver, human hepatoma, and normal, regenerating and fetal rat liver. Journal
of Clinical Investigation
81:976-981, 1988.
2. Poulos, J.E., E.L. Treadwell, K.
O'Brien, and J.F. Caro. The presence of
autoantibodies to
the IGF-1, IGF-2, and insulin receptor
in patients with Type II diabetes, impaired glucose
tolerance or autoimmune diseases. Advances
en Diabetologia 3:83-94, 1990.
3. Kalmus, G.W., J.E. Poulos, and C.W.
O'Rear. The effects of Indomethacin on
fibroblast
chemotaxis. General Pharmacology 23:571-574, 1992.
4. Poulos, J.E., S.R. Johnson, P.
Conrad, and D. Vesely. The dome lesion
on chest X-ray:
Retroperitoneal abscess dissecting
through the posterior chest wall. Southern Medical Journal
87:77-80, 1994.
5. Caro, J.F., M.S. Raju, C.J., Lynch, and J.E.
Poulos. Guanine nucleotide binding
regulatory
proteins in liver from obese humans with
and without Type II diabetes: Evidence
for altered
"cross-talk" between the
insulin receptor and Gi proteins. Journal of Cellular Biochemistry
54:309-319, 1994.
6. Poulos, J.E., G.W. Kalmus, and C.W.
O'Rear. Fibroblast chemotaxis in
response to
dexamethasone. In Vitro 30:651-652, 1994.
7. Poulos, J.E., N. Frazier, P.
Khanzie, S. Long, K MacDonald, and J.F. Caro.
Circulating
insulin-like growth factor 1
concentrations in morbidly obese patients with NIDDM in
response to the gastric bypass
procedure. Hormone and Metabolic Research
26:478-480,
1994.
8. Poulos, J.E., H.J. Nord, and P. Altus. Non 0-1 Vibrio cholerae septicemia and
neutrocytic
ascites in a patient with chronic liver
disease. Journal of the Florida Medical Association 12:9-
12,
1994.
9. Poulos, J.E., J. Serrano, T. Madigan, R. Ravindra, and J.F.
Caro. The effect of GTPyS on
insulin binding to human liver plasma
membranes. Hormone and Metabolic Research
27:253-
254, 1995.
10. Poulos,
J.E., W. Gower, G.W. Kalmus, and D.L. Vesely. Cirrhosis with ascites:
Increased
ANF peptide mRNA synthesis in rat
ventricle. Gastroenterology
108:1496-1503, 1995.
11.
Phuphanich, S., L. Jacobs, J.E. Poulos, and D.L. Vesely. Hypoglycemia secondary to a
malignant meningioma. American
Journal of the Medical Sciences 309:1496-1503, 1995.
12. Poulos,
J.E., W. Gower, F. Friedl, and D.L. Vesely. Atrial natriuretic peptide gene
expression within invertebrate
hearts. General and Comparative Endocrinology 100:61-68,
1995.
13. Poulos,
J.E. and B.R. Bacon. Liver
transplantation for hereditary hemachromatosis.
Digestive
Diseases 14:316-322, 1996.
14. Poulos,
J.E., W. Gower, H. Fontanet, and D.L. Vesely. Congestive heart failure increased
atrial natriuretic peptide mRNA in rat
stomach antrum. Cardiovascular Research 32:909-
919, 1996.
15.
Brown, K.E., J.E. Poulos, A. Soweid, R. O'Neil, R.S. Britton, and B.R.
Bacon. The effect of
vitamin E administration on chronic
dietary iron overload. American Journal of Physiology
272:G116-G123, 1997.
16. Poulos,
J.E., M.E. Presti, N. Phillips, W.E. Longo. Presentation and management of
lymphatic cyst of the colon. Diseases
of the Colon and Rectum 40:366-369,
1997.
17. Poulos,
J.E., J.M. Bellezzo, J.D. Weber, A.M. Di Bisceglie, R.S. Britton, B.R.
Bacon, and
J.J. Baldassare. Fibronectin and cytokines stimulate JNK,
ERK, AP-1 activity and transin
gene expression in rat hepatic stellate
cells. American Journal of Physiology 273:G804-811,
1997.
18. Poulos,
J.E., S. Joshi, and M.E. Presti.
Pneumatosis Intestinalis. Gastroenterology. 116:6,
1999.
19.
Fan, X., H. Solomon. J.E. Poulos,
B.A. Neuschwander-Tetri, and A.M. Di Bisceglie.
Comparison of hepatitis C viral
quasispecies in serum and liver tissue.
American Journal of
Gastroenterology. 1999
94:1347-1354.
20.
Aranda-Michel, J., A. Koehler, P.A. Bejarano.
J.E. Poulos. B.A. Luxon,
C.M. Khan.
Nefazodone-induced liver failure: Report of three cases. Ann.
Intern Med. 1999 130:285-288.
21. Poulos,
J.E., J.D. Weber, B. Neuschwander-Tetri, L. Wells, P. Petersen, R.S.
Britton,
B.R. Bacon and J.J. Baldassare. Hepatic stellate cell (HSC) thiol status
influences integrin
activation of extracellular regulated
signal kinase (ERK) and AP-1 dependent gene
transcription. American Journal of
Physiology (submitted).
22. Poulos,
J.E., E. Brunt, L. Li, H. Solomon, R.S. Britton, B.R. Bacon, and A.M. Di
Bisceglie.
Alpha smooth muscle expression in
chronic hepatitis C. American Journal of Gastroenterology
(submitted).
23.
Neuschwander-Tetri, B.A., F.R. Burton, M.E. Presti, R.S. Britton, C.G. Janney,
P.R. Garvin,
E.M. Brunt, J.F. Galvin and J.E. Poulos.
Chronic pancreatitis in the mouse caused by repetitive injury.
American
Journal of Pathology (submitted).
ABSTRACTS/PRESENTATIONS:
1. Poulos, J.E. and G.W. Kalmus. Thrombin as a possible chemoattractant for
fibroblasts.
Journal
of the Elisha Mitchell Scientific Society.
102:172, 1986.
Presented at the annual meeting of the
North Carolina Academy of Science, 1986.
2. Poulos, J.E. and G.W. Kalmus. The effects of an anti-inflammatory agent on fibroblast
chemotaxis. Amer. Zoologist 127:143, 1987.
3. Poulos, J.E. and G.W. Kalmus. The effects of dexamethasone and
Indomethacin on
fibroblast chemotaxis. Presented at the annual meeting of the
Association of Southeastern
Biologists, 1987, and the Southeastern
Regional Developmental Biology Conference, 1988.
4. Poulos, J.E., N. Frazier, P.
Khanzie, S. Long, K. MacDonald, and J.F. Caro.
Circulating
insulin-like growth factor 1
concentrations in morbidly obese patients with NIDDM in
response to the gastric bypass
procedure. Presented at the annual
meeting of the National
Student Research Forum, 1989.
5. Poulos, J.E., W. Gower, G.W. Kalmus,
and D.L. Vesely. Increased
gastrointestinal ANF
peptide mRNA synthesis in cirrhosis and
congestive heart failure. Presented at
the annual
meeting of the American College of
Physicians Florida Chapter Meeting, 1993.
6. Poulos, J.E., W.R. Gower, H.
Fontanet, and D.L. Vesely. Cirrhosis
with ascites: Increased
atrial natriuretic peptide messenger RNA
synthesis in rat ventricle. American
Journal of
Gastroenterology 89:1676A,
1994. Presented at the annual meeting
of the American
College of Gastroenterology, 1994.
7. Poulos, J.E., A.M. Di Bisceglie,
R.S. Britton, B.R. Bacon, J.D. Weber, J.M. Bellezzo, and
J.J. Baldassare. Stimulation of c-Jun kinase by fibronectin
and interleukin-1 is associated
with increased gene expression of
stromelysin in lipocytes. Hepatology 22:293A, 1995.
Presented as an oral presentation at the
annual meeting of the American Association for the
Study of Liver Diseases, 1995, and at
the annual meeting of the Astra Merck Young
Investigators Conference, 1995.
8. Li, L., R. O'Neill, K. E. Brown, A.M.
Soweid, R.S. Britton, J.E. Poulos, and B.R. Bacon.
Vitamin E suppresses lipocyte activation
in chronic iron overload. Hepatology 22:279A,
1995.
Presented at the annual meeting of the American Association of the Study
of Liver
Diseases, 1995.
9. Poulos, J.E., E.M. Brunt, C.G.
Janney, B.R. Bacon, and A.M. Di Bisceglie.
Hepatic
expression of alpha smooth muscle actin
in chronic hepatitis C: Correlation
with disease
activity and changes with therapy. Hepatology
22:278A, 1995. Presented at the annual
meeting of the American Association for
the Study of Liver Diseases, 1995.
10. Poulos,
J.E., K. E. Brown, A. Soweid, R. O'Neil, R.S. Britton, B.R. Bacon. The effect of
vitamin E administration on chronic
dietary iron overload. Presented at the annual meeting of
the American College of Physicians,
1996.
11. Poulos,
J.E. and D.L. Vesely. Hypoglycemia
secondary to a malignant meningioma.
Presented at the annual meeting of the
American College of Physicians, 1996.
12. Poulos,
J.E., J.M. Bellezzo, J.D. Weber, A.M. Di Bisceglie, R.S. Britton, B.R.
Bacon, and
J.J. Baldassare. Fibronectin and Interleukin-1a stimulate AP-1 dependent gene
expression in
rat hepatic stellate cells. Hepatology
24: 459A, 1996. Presented at the
annual meeting of the
American Association for the Study of
Liver Diseases, 1996.
13.
Fan, X., B.A. Neuschwander-Tetri, J.E. Poulos, H. Solomon, A.M. Di
Bisceglie. Hepatic
HCV RNA in alcoholic patients undergoing
liver transplantation. Hepatology 24:508A,
1996.
Presented at the annual meeting of the American Association for the
Study of Liver
Diseases, 1996.
14. Poulos,
J.E., J.D. Weber, J.J. Baldassare, L. Li, R.S. Britton, and B.R.
Bacon. Activation of
mitogen-activated protein kinase
pathways by tumor necrosis factor-a
and fibronectin in rat
hepatic stellate cells. Gastroenterology 112:1361A, 1997. Presented as an oral presentation
at the annual meeting of the American
Gastroenterological Association, 1997.
15. Poulos,
J.E., J.D. Weber, B.A. Neuschwander-Tetri, L. Wells, P. Petersen, J.J.
Baldassare,
R.S. Britton, and B.R. Bacon. Hepatic stellate cell (HSC) thiol status
influences integrin
activation of extracellular regulated
signal kinase (ERK) and AP-1 dependent gene
transcription. Hepatology 26:507A, 1997.
Presented at the annual meeting of the American
Association for the Study of Liver
Diseases, 1997.
16.
Fan, X., H. Solomon, J.E. Poulos, B.A. Neuschwander-Tetri, and A.M. Di
Bisceglie. A
comparison of hepatitis C viral
quasispecies in liver and serum. Hepatology 26:123A, 1997.
Presented at the annual meeting of the
American Association for the Study of Liver Diseases,
1997.
17.
Fan, S., H. Solomon, B.A. Neuschwander-Tetri, J.E. Poulos, and A.M. Di
Bisceglie. Is
hepatitis G. virus hepatotrophic?: Detection of HGV RNA in serum and liver
tissue of
patients undergoing liver
transplantation. Hepatology 26:210A,
1997. Presented at the
annual meeting of the American
Association for the Study of Liver Diseases, 1997.
18.
M.A. Anbari, J.E. Poulos, M.T. Milliano, and B.A. Luxon. a5
and B1 integrin subunit
expression in hepatic stellate cells is
regulated by extracellular matrix proteins.
Gastroenterology 114:10020A, 1998. Presented at the annual meeting of the American
Gastroenterological Association, 1998.
19.
B.A. Neuschwander-Tetri, L.D. Wells, and J.E. Poulos. Pancreatic alpha smooth muscle
actin and collagen 1 expression in a
murine model of progressive pancreatic fibrogenesis.
Gastroenterology 114:G1978A, 1998. Presented at the annual meeting of the American
Gastroenterological Association, 1998.
20. Poulos,
J.E., J.D. Weber, B.A. Neuschwander-Tetri, L. Wells, P. Petersen, J.J.
Baldassare, R.S.
Britton, and B.R. Bacon. Map kinase signaling pathways in hepatic
stellate cells. Presented at
grand rounds at the Medical College of
Georgia, 1998.
21.
Li, J.J., W. Hu, J.J. Baldassare, L. Li, S. Chen, J.E. Poulos, R.
O’Neill, R.S. Britton, and B.R.
Bacon.
Extracellular signal-regulated kinase (ERK) links platelet-derived
growth factor (PDGF)
signaling to the cell cycle machinery in
hepatic stellate cells. Hepatology 28:1090A, 1998.
Presented at the annual meeting of the
American Association for the Study of Liver Diseases,
1998.
22.
Li, J.J., W. Hu, J.J. Baldassare, J.E. Poulos, S. Chen, L. Li, P.S.
Bora, B.A. Neuschwander-
Tetri, R. O’Neill, R.S. Britton, and B.R.
Bacon. The ethanol metabolite,
linolenic acid ethyl
ester, stimulates mitogen-activated
protein (MAP) kinase and cyclin signaling in hepatic stellate
cells.
Hepatology 28:559A, 1998. Presented at the annual meeting of the
American Association
for the Study of Liver Diseases,
1998.
23. Poulos,
J.E. Update in H. pylori induced
peptic ulcer disease. Presented at the
annual meeting
of the Robeson County Medical Society,
1998.
24.
Li, J.J., W. Hu, J.J. Baldassare, S. Chen, L. Li, J.E. Poulos, R.
O’Neill, R. Britton.
Pentoxifylline inhibits the effect of
platelet-derived growth factor on regulatory cell-cycle
proteins in hepatic stellate cells. Gastroenterology
116:A1238, 1999.
25. Poulos,
J.E., J.R. Jones, V.P. Kodali, W.F. Vorder Bruegge. A community experience with
endoscopic hemorrhoidal ligation (EHL)
utilizing the Saeed six shooter. Gastroenterology
116:A89, 1999.