CURRICULUM
VITAE
DIMITER HRISTOV
ZAFIROV, M.D.
M.D., 9/65-12/71 Higher
Medical Institute, Varna, Bulgaria.
Specialty in
Pharmacology, 1976-1980.
Higher Medical
Institute, Sofia, Bulgaria.
8/97-7/00 FELLOW GASTROENTEROLOGY, MCP Hanneman
University, Graduate Hospital, Philadelphia, PA 19146.
8/94-7/97 RESIDENT in INTERNAL MEDICINE, Northeastern
Ohio University College of Medicine, Affiliated Hospitals at Canton, Ohio.
2/93-7/94 USMLE Steps 1 and 2.
7/90-1/93
VISITING RESEARCHER, Department of Physiology, College of Medicine, Ohio State
University, Columbus, Ohio.
Gastrointestinal effects of hormones, cytokines and neurotransmitters.
5/85-6/90 ASSISTANT PROFESSOR, Departments of Internal
Medicine and Pharmacology, Higher Medical Institute, Sofia, Bulgaria. Attending physician, teaching, research in
gastroenterology.
1/84-4/85 VISITING SCIENTIST, Department of
Physiology, School of Medicine, University of Nevada, Reno, Nevada. Investigated the effects of several
brain-gut peptides, serotonin, histamine and purine nucleotides on the
gastrointestinal tract.
1/74-1/84
ASSISTANT PROFESSOR, Departments of Internal Medicine and Pharmacology, Higher
Medical Institute, Sofia, Bulgaria.
Attending physician, teaching, research in gastroenterology.
3/72-12/73
ATTENDING PHYSICIAN, Medical Corps, Army of the Republic of Bulgaria. Fulfilled military service requirement as an
Attending Physician in the Department of Internal Medicine in a military
hospital.
1/71-1/72
RESIDENT INTERNAL MEDICINE, University Hospitals, Varna, Bulgaria.
1985
certificate of merit FOR ACHIEVEMENT AS Visiting Scientist, presented by the
Dean of the School of Medicine, University of Nevada, Reno, Nevada.
1971
SECOND IN THE MEDICAL CLASS OF 1971 and noted on the list as an “outstanding
Graduate” from the Higher Medical Institute, Varna, Bulgaria.
1965
FIRST IN THE CLASS OF 1965, and awarded the Golden Medical from District Three
High School in Varna, Bulgaria.
1.
Petkov,
P., E. Konstantinova, D. Zafirov,
and S. Stancheva, 1976. Changes in the
Content of Biogenic Monoamines in Various Cerebral Regions under the Influence
of Centrophenoxine. Exp. Med. Morphol.,
15:233-236 (in Bulgarian).
2.
Popova,
N., I. Petkova, R. Kolarova, and D.
Zafirov, 1977. Participation of
Cyclic 3’, 5’-Adenosine Monophosphate in the Pathogenesis of Myocardial
Hypertrophy during Experimental Hypertension.
Exp. Med. Morphol., 16:207-211.
3.
Petkov,
V., D. Zafirov, Y. Panova, S. Yanev,
and S. Stanche va, 1978. On the
Participation of the Cyclic 3’, 5’-AMP System and of the Brain Biogenic
Monoamines in the Mechanism of the Centrophenoxine Action. In:
On the Pharmacology of Centrophenoxine, ed. V. Petkov, Publishing House
of the Bulg. Acad. Sci., Sofia, 28-33.
4.
Vlahov,
V., D. Zafirov, V. Mutafova, and I.
Velinov, 1979. A New Device for
Measurement of the Volume of Experimental Inflammation. In:
Innovations and Instrumentations in Medicine, ed. by INRA, Sofia, 13:
13-15.
5.
Vlahov,
V., D. Zafirov, and D. Zeljazkov,
1980. The Effects of Isoteolin on the
Cerebral Blood Flow. Advances in
Internal Medicine, 8: 19-24 (in Bulgarian).
6.
Vlahov,
V., I. Chakarski, D. Zafirov, A.
Chaushev, G. Stefa nov, A. Koichev, and A. Bogdanova, 1980. Experimental and Clinical Studies of
Laxative Action of Herbal Combinations in Patients with Obstipation
Syndrome. Advances in Internal
Medicine, 8: 60-68.
7.
Vlahov,
V., D. Zafirov, 1981. The Cyclic AMP Level during an Increased
Blood Flow in Cat Cerebral Cortex. Acta
Physiol. Pharmacol. Bulg., 7: 61-68.
8.
Ivancheva,
S., V. Vlahov, I. Chakarski, and D.
Zafirov, 1981. Experimental and
Clinical Investigations of a New Herbal Combination with Laxative Effects. Pharmacy, 31: 45-46.
9.
Papasova,
M., A. Bonev, K. Boev, D. Zafirov,
and S. Gachilo va, 1982. Effects of
4-Aminophyradine on Neurotransmission in Smooth Muscle. Agressology, 23: 99-103.
10.
Zafirov, D., G. Bready-Dobreva, K. Boev,
and M. Papasova, 1983. Ionic
Interactions in the Smooth Muscles of Cat Pulmonary Artery and Portal
Vein. Acta Physiol. Pharmacol. Bulg.,
9: 54-62.
11.
Bready-Dobreva,
G., D. Zafirov, 1984. Effect of PGE2 on Isolated Renal
Artery from Rabbit. Biomed. Biochem.
Acta, 43: S307-S310.
12.
Nemeth,
P.R., D.H. Zafirov, and J.D. Wood,
1984. Forskolin Mimics Slow Synaptic
Excitation in Myenteric Neurons. Eur.
J. Pharmacol., 101: 303-304.
13.
Carey,
H.V., H.J. Cooke, P.R., Nemeth, D.H.
Zafirov, and J.D. Wood, 1985.
Nerve-mediated Action of Forskolin on Guinea-pig Ileal Mucosa. Experientia, 41: 1156-1158.
14.
Nemeth,
P.R., C.A. Ort, D.H. Zafirov, and
J.D. Wood, 1985. Interactions Between
Serotonin and Cisapride on Myenteric Neurons.
Eur. J. Pharmacol., 108: 77-83.
15.
Nemeth,
P.R., D.H. Zafirov, and J.D. Wood,
1985. Effects of Cholecystokinin,
Caerulein and Pentagastrin on Electrical Behavior of Myenteric Neurons. Eur. J. Pharmacol., 116: 263-269.
16.
Zafirov, D.H., J.M. Palmer, and J.D. Wood,
1985. Adenosine Inhibits
Forskolin-induced Excitation in Myenteric Neurons. Eur. J. Pharmacol., 113: 143-144.
17.
Zafirov, D.H., J.M. Palmer, P.R. Nemeth,
and J.D. Wood, 1985. Bombesin, Gastrin
Releasing Peptide and Vasoactive Intestinal Peptide Excite Myenteric
Neurons. Eur. J. Pharmacol., 115: 103-107.
18.
Zafirov, D.H., J.M. Palmer, and J.D. Wood,
1985. Cyclic 3’, 5’-Adenosine
Monophosphate Mimics Slow Synaptic Excitation in Myenteric Plexus Neurons. Brain Res., 347: 368-371.
19.
Nemeth,
P.R., J.M. Palmer, J.D. Wood, and D.H.
Zafirov, 1986. Effects of Forskolin
on Electrical Behavior of Myenteric Neurons in Guinea-pig Small Intestine. J. Physiol., 376: 439-450.
20.
Palmer,
J.M., J.D. Wood, and D.H. Zafirov,
1986. Elevation of Adenosine 3’,
5’-Phosphate Mimics Slow Synaptic Excitation in Myenteric Neurons of the
Guinea-pig. J. Physiol., 376: 451-460.
21.
Palmer,
J.M., J.D. Wood, and D.H. Zafirov,
1987. Purinergic Inhibition in the
Small Intestinal Myenteric Plexus of the Guinea-pig. J. Physiol., 387: 357-369.
22.
Palmer,
J.M., J.D. Wood, D.H. Zafirov,
1987. Transduction of Aminergic and
Peptidergic Signals in Enteric Neurons of the Guinea-pig. J. Physiol., 387: 371-383.
23.
Bready-Dobreva,
G., D. Zafirov, K. Nieber, P. Oehme,
and M. Papasova, 1988. Effects of
Substance P on Isolated Preparations from Rabbit and Rat Renal Arteries. Biomed. Biochem. Acta, 47(1): 25-30.
24.
Zafirov, D.H., 1988. Haloperidol, Chlorpromazine, and Lithium
Chloride Antagonize the Excitatory Action of Forskolin and of Some Gut Peptides
on Guinea-pig Myenteric Neurons. Acta
Physiol. Pharmacol. Bulg., 14: 17-25.
25.
Bready-Dobreva,
G., D. Zafirov, K. Nieber, P. Oehme,
and M. Papasova, 1989. A New Analogue
of Substance P with Antagonistic Properties in Renal and Pulmonary
Arteries. Acta Physiol. Pharmacol.
Bulg., 15: 10-15.
26.
Zafirov, D., G. Bready-Dobreva, V.
Litchev, and M. Papasova, 1990.
Antiexudative and Capillarytonic Effects of Procyanidines isolated from
Grape Seeds. Acta Physiol. Pharmacol.
Bulg., 16: 50-54.
27.
Zafirov, D., G. Bready-Dobreva, and M.
Papasova, 1990. Effects of Forskolin on
Contractions and Release of Noradrenaline in Renal Arteries. Comptes Rendus de l ’Academie Bulgare des
Sciences, 43: 113-115.
28.
Zafirov, D.H., H.J. Cooke, and J.D. Wood,
1991. Vasoactive Intestinal Peptide
(VIP) and Thyrotropin-releasing Hormone (TRH) Mimic Slow Excitatory Potentials
in Submucous Neurons of Guinea-pig Small Intestine. J. Gastrointestinal Motility, 3: 209.
29.
Zafirov, D.H., H.J. Cooke, and J.D. Wood,
1991. Thyrotropin-releasing Hormone
Excites Submucous Neurons in Guinea-pig Ileum.
Eur. J. Pharmacol., 204: 109-112.
30.
Zafirov, D.H., J.D. Wood, 1991. Peptidergic Modulation of the Excitability
in the Guinea-pig Myenteric Neurons.
In: Central and Peripheral
Peptidergic Regulation, ed. V. Klusa, Latvian Academy of Sciences, Riga, 83-99.
31.
Zafirov, D.H., H.J. Cooke, and J.D. Wood,
1992. Elevation of cAMP Facilitates
Noradrenergic Transmission in Submucous Neurons of Guinea-pig Ileum. Am. J. Physiol., (in press).
32.
Zafirov, D.H., Y. Xia, and J.D. Wood, 1995. Actions of Daiichi DQ-2511 on Electrical and
Synaptic Behavior of Enteric Neurons in the Guinea-pig Small Intestine, (in
press).
1.
Zafirov, D., S. Stancheva, 1976. Studies on the Spasmolytic Action of the
Total Coumarin Mixture of Peucedanum Arenarium W. K. and of the Flavonoids from
Crataegus Monogyna. Proc. of the
Intern. Symp. “Physiology and Pharmacology of Smooth Muscle,” Varna, Bulgaria,
83.
2.
Popova,
N., R. Kolarova, I. Petkova and D. Zafirov, 1976. The Effect of Beta-adrenergic Blockade on
the Level of Cyclic AMP in Rat Myocardium after Experimental Hypertension. Proc. of the 6th Natl. Congress
of Internal Diseases, Plovdiv, Bulgaria, 11.
3.
Petkov,
V., D. Zafirov, E. Konstantinova, V.
Kuchev, Y. Panova, S. Yanev and S.
Stancheva, 1976. Centrophenoxine,
Biogenic Monoamines and Cyclic AMP in the Brain. Proc. of the 4th Natl. Conference “Pharmacological and
Clinical Studies of New Drugs,” Sofia, Bulgaria, 231-232.
4.
Zafirov, D., V. Vlahov, 1978. Cyclic AMP Level during C02-induced
Vasodilation in the Gray Matter of Cat Cerebral Cortex. Proc. of the 3rd Internatl.
Congress of Pathophysiology, Varna, Bulgaria, 156.
5.
Vlahov,
V., S. Dimitrova, D. Zafirov, and V.
Mutafova, 1978. The Effects of Cinnarizine,
Aligeron and Piracetam on the Cortical Blood Flow and on the Arterial and
Venous 02, C02 and pH. Proc. of the First Natl. Congress
of Pharmacology, Sofia, Bulgaria, 16-17.
6.
Vlahov,
V., D. Zafirov, and D. Zeljazkov,
1978. Measurements of the Changes in
the Brain Volume and Cerebrospinal Liquo Pressure during Experimental Brain
Oedema. Ibidem, 17-18.
7.
Zafirov, D., V. Vlahov, 1978. Cyclic AMP and Dilation of the Cerebral
Blood Vessels in Cat. Ibidem, 33-34.
8.
Vlahov,
V., D. Zafirov, 1979. The Role of Adenosine Nucleotides in the
Mechanism of Cerebral Cortical Vasodilation.
Proc. of the 3rd Congress of the Hungarian Physiol. Soc.,
Budapest, Hungary, 99.
9.
Bacracheva,
N., V. Vlahov, and D. Zafirov,
1981. Experimental Evidence for
Venotonic Action of Extracts from the Potentilla Species. Proc. of the 5th Natl. Conference
“Pharmacological and Clinical Studies of New Drugs,” Sofia, Bulgaria, 47.
10.
Bonev,
A., D. Zafirov, 1981. Influence of 4-Aminopyridine on
Neurotransmission in the Smooth Muscle of Cat Stomach. Proc. of the Conference for Young Scientists
in Neurobiology, Sofia, Bulgaria, 8.
11.
Papasova,
M., A. Bonev, K. Boev, D. Zafirov,
and S. Gachilo va, 1981. Effect of
4-Aminopyridine on Neurotransmission in Smooth Muscle. Internatl. Symp. “Pharmacology of
Transmitter Interactions,” Sofia, Bulgaria, 43.
12.
Zafirov, D., G. Dobreva, and M.
Papasova, 1982. Sodium-calcium
Interactions in Vascular Smooth Muscle.
Proc. of the 3rd Internatl. Symp. “Physiology and
Pharmacology of Smooth Muscle,” Varna, Bulgaria, 128.
13.
Bready-Dobreva,
G., D. Zafirov, 1984. Prostaglandins and Excitation-Contraction in
Renal Arteries of Rabbit. Second Natl.
Congress of Physiology, Plovdiv, Bulgaria, 26.
14.
Bready-Dobreva,
G., D. Zafirov, 1984. Effect of PGE2 on Isolated Rabbit
Renal Artery. Fourth Internatl.
Symposium on Prostaglandins, Thromboxane and Leukotriens, Halle, Germany, 91.
15.
Nemeth,
P.R., C.A. Ort, D.H. Zafirov, and
J.D. Wood, 1984.
Cholecystokinin-Octapeptide and Caeruein but not Pentagastrin Alter
Electrical Behavior or Myenteric Neurons in Guinea-pig Ileum. Dig. Dis. Sci., 29: 559.
16.
Zafirov, D.H., P.R. Nemeth, J.M. Palmer,
and J.D. Wood, 1984. Forskolin Mimics
Slow Synaptic Excitation in Myenteric Neurons.
Neurosci. Abstr., 10: 1101.
17.
Ort,
C.A., P.R. Nemeth, D.H. Zafirov, and
J.D. Wood, 1984. Cisapride Blocks the
Action of Serotonin on Myenteric Neurons.
Neurosci. Abstr., 10: 275.
18.
Zafirov, D.H., J.M. Palmer, P.R. Nemeth,
and J.D. Wood, 1985. Mechanism of
Excitatory Action of Bombesin, Gastrin-Releasing Peptide and Vasoactive
Intestinal Polypeptide on Guinea-pig Myenteric Neurons. Fourth Internatl. Symposium “Physiology and
Pharmacology of Smooth Muscle,” Varna, Bulgaria, 133.
19.
Wood,
J.D., D.H. Zafirov, J.M. Palmer, and
P.R. Nemeth, 1985. Elevation of
Intraneuronal Cyclic AMP Mimics Slow Synaptic Excitation in Myenteric
Neurons. Ibidem, 131.
20.
Palmer,
J.M., D.H. Zafirov, P.R. Nemeth, and
J.D. Wood, 1985. Electrophysiological
Evidence for Second Messenger Function of Cyclic AMP in the Enteric Nervous
System at Guinea-pig Small Intestine.
Gastroenterology, 88: 1528.
21.
Wood,
J.D., D.H. Zafirov, and J.M. Palmer,
1985. Activation of Adenylate Cyclase
by Gastrointestinal Messenger Substances in the Enteric Nervous System of
Guinea-pig Small Intestine.
Gastroenterology, 88: 1635.
22.
Palmer,
J.M., D.H. Zafirov, P.R. Nemeth, and
J.D. Wood, 1985. Peptidergic Modulation
of excitability in Myenteric Plexus Neurons.
Dig. Dis. Sci., 30: 786.
23.
Wood,
J.D., D.H. Zafirov, and J.M. Palmer,
1985. Gastrointestinal Messenger
Substances Modulate Excitability in Myenteric Plexus Neurons through Activation
of Adenylate Cyclase. Neurosci. Abstr.,
11: 113.
24.
Palmer,
J.M., D.H. Zafirov, P.R. Nemeth, and
J.D. Wood, 1985. Second Messenger
Function of Cyclic AMP Mediates Modulation of Excitability in Myenteric Plexus
Neurons. Neurosci. Abstr., 11: 813.
25.
Bready-Dobreva,
G., D. Zafirov, K. Nieber, P. Oehme,
and M. Papasova, 1986. Modulation of
Neurotransmission in Arteries by Substance P.
Second Int. Symposium “Pharmacology of Transmitter Interactions,” Sofia,
Bulgaria, 18.
26.
Bready-Dobreva,
G., D. Zafirov, K. Nieber, P. Oehme,
and M. Papasova, 1986. Interactions
between Substance P and a Putative Antagonist of Substance P. Proc. of the 4th Natl. Congress
of Physiology, Blagoevgrad, Bulgaria, 63.
27.
Palmer,
J.M., D.H. Zafirov, K. Tamura, M.
Schemann, and J.D. Wood, 1986.
Purinergic Compounds Suppress Neuronal Excitability in the Myenteric
Plexus of Guinea-pig Small Intestine.
Gastroenterology, 90: 1576.
28.
Palmer,
J.M., D.H. Zafirov, and J.D. Wood,
1986. Complains of-modulation of
Excitability in Myenteric Plexus Neurons by Peptides and purines. Symposium “Smooth Muscle Function,” Banff,
Alberta, Canada, 121, 10-P5.
29.
Zafirov, D., J. Wood, 1986. Effects of Brain-Gut Peptides on the
Intramural Neurons of Guinea-pig. Proc.
of the 4th Natl. Congress of Physiology, Blagoevgrad, Bulgaria, 63.
30.
Zafirov, D.H., J.M. Palmer, and J.D. Wood,
1986. Adenosine Antagonizes the Slow
Synaptic Excitation in the Myenteric Plexus Neurons Caused by Some Gut
Peptides. Second Int. Symposium
“Pharmacology of Transmitter Interactions,” Sofia, Bulgaria, 18.
31.
Zafirov, D., J. Wood, 1986. Role of Cyclic AMP in Modulation of
Excitability of Neurons from Guinea-pig Small Intestine Myenteric Plexus. Ibidem, 67.
32.
Zafirov, D.H., G. Bready-Dobreva, and M.
Papasova, 1986. Effects of Substance P
on Neurotransmission in Arteries from Normal and Hypertensive Animals. XXX Internatl. Congress of Physiol. Sci.,
Vancouver, Canada, 292.6.
33.
Zafirov, D.H., J.M. Palmer, K. Tamura, and
J.D. Wood, 1986. Neuromodulatory
Interactions between Peptidergic and Purinergic Messenger Substances in the
Enteric Nervous System. XXX Internatl.
Congress of Physiol. Sci., Vancouver, Canada, 437.
34.
Bready-Dobreva,
G., D. Zafirov, K. Nieber, and P.
Oehme, 1987. New Analogue of Substance
P which Antagonized the Vascular Effects of Substance P. Internatl. Symposium “Physiology of
Peptides,” Leningrad, USSR, 27.
35.
Zafirov, D.H., J.D. Wood, 1987. Mechanisms of Peptidergic and Aminergic
Postsynaptic Excitation of the Neurons from Myenteric Ganglia. Third Internatl. Symposium and School for
Young Scientists “CNS and Peripheral Synapsis,” Varna, Bulgaria, 89.
36.
Zafirov, D.H., G. Bready-Dobreva, K.
Nieber, P. Oehme, and M. Papasova, 1987.
Effects of Substance P and of a Putative Antagonist of Substance P on
Isolated Arteries. The Second World Congress
of Neuroscience, 973P.
37.
Bready-Dobreva,
G., D. Zafirov, K. Nieber, P. Oehme,
and M. Papasova, 1988. Mechanisms of
Action of Substance P on Arteries.
Internatl. Symposium “Physiology and Pharmacology of Smooth Muscle,”
Varna, Bulgaria, 41.
38.
Bready-Dobreva,
G., D. Zafirov, K. Nieber, P. Oehme,
and M. Papasova, 1988. Substance P as
Regulator of the Contractile Activity of the Vascular Smooth Muscle. Symposium “Basic and Applied Aspects of
Muscle Physiology,” Reinchardsbrun, Germany.
39.
Zafirov, D., J. Wood, 1988. Peptidergic and Aminergic Regulation of
Activity of Myenteric Neurons.
Symposium “Physiology of Peptides,” Leningrad, USSR, 70-71.
40.
Zafirov, D., 1989. Involvement of Second Messenger Systems in
Peptidergic and Aminergic Modulation of Excitability of Guinea-pig Myenteric
Neurons. Internatl. School of Molecular
Neurobiology, 8-15 May, Madralin, Poland.
41.
Zafirov, D., G. Bready-Dobreva, and M.
Papasova, 1989. Forsko lin Effects on
Contractions and Noradrenaline Release in Rabbit and Dog Renal Arteries. XXXI Internatl. Congress of Physiological
Sci., Helsinki, Finland, P4379.
42.
Zafirov, D., G. Bready-Dobreva, and M.
Papasova, 1990. Role of Cyclic AMP in
Relaxation and Neurotransmission in Renal Arteries. Third Internatl. Symposium “Pharmacology of Transmitter Interactions,”
Sofia, Bulgaria, 100.
43.
Zafirov, D.H., H.J. Cooke, and J.D. Wood,
1991. Electrophysiologic Evidence for
Involvement of Adenylate Cyclase in Adrenergic Transmitter Release in
Guinea-pig Submucous Plexus. Regional
Meeting of the IUPS, Prague, Czechoslovakia, (Abstr.), p. 128.
44.
Xia,
Y., D.H. Zafirov, P. Mohanraj, H.J.
Cooke, and J.D. Wood, 1995.
Identification of Tachykinin Receptors ob Neurons Identified
Morphologically in the Mucous and Submucous Plexuses of Guinea-pig Small
Intestine. Digestive Disease Week, May
14-17 1995, San Diego, CA, Abstracts 3627.